Core facilities

Tissue Bank Bern TBB

Tissue Bank Bern TBB

The Tissue Bank Bern (TBB) manages samples and patient information from the Inselspital and additional clinics in the surroundings of the Institute of Pathology Bern according to the Human Research Act (Humanforschungsgesetz, HFG) and international guidelines. We also ensure high quality tissue samples for research purposes throughout their collection, processing, storage, and distribution.

statistics

The number of specimens in TBB is growing every year and  now consists of more than 10`000 different samples, bringing the total number of fresh-frozen stored tissue aliquots to > 37’000. Samples are mainly derived  from the following clinical departments: The Women’s Clinic (Frauenklinik), Urology, Visceral Surgery,  Thoracic surgery and Ear, Nose, Throat Clinic (ENT). The size of the boxes found on the graph corresponds to the relative number of samples in TBB from each specific clinic.

Projects and collaborations

Tissue for researchers

The number of TBB projects continues to rise. In 2017, we provided more than 300 tissues to researchers including fresh and snap-frozen samples. A representation of tissue types and number provided by TBB is shown below.

Bridging Biobank Bern

TBB along with the Liquid Biobank (LBB) of the Insel Hospital have now a shared steering committee to oversee both biobanks, a common website www.biobankbern.ch and harmonized Reglement. TBB and LBB together are continuously trying to optimize common workflows for research.

PathoLink

TBB collaborates with the Swiss Biobanking Platform (SBP) to help standardize and harmonize biobanking procedures across Switzerland

Adopt BBMRI-ERIC

TBB has contributed to the colorectal cancer cohort (CRC-Cohort) which is expected to enable high-quality research and innovation to improve colorectal cancer treatment.

References

The TBB has been referenced in numerous articles this year.

 1. Trippel M, Imboden S, Papadia A, Mueller MD, Mertineit N, Härmä K, Nicolae A, Vassella E, Rau TT. Intestinal differentiated mucinous adenocarcinoma of the endometrium with sporadic MSI high status: a case report. Diagn Pathol. 2017 May 12;12(1):39. doi: 10.1186/s13000-017-0629-0. PubMed PMID: 28494767; PubMed Central PMCID: PMC5427532.

2. Ghadjar P, Hayoz S, Genitsch V, Zwahlen DR, Hölscher T, Gut P, Guckenberger M, Hildebrandt G, Müller AC, Putora PM, Papachristofilou A, Stalder L, Biaggi-Rudolf C, Sumila M, Kranzbühler H, Najafi Y, Ost P, Azinwi NC, Reuter C, Bodis S,Khanfir K, Budach V, Aebersold DM, Thalmann GN; Swiss Group for Clinical Cancer Research (SAKK). Importance and outcome relevance of central pathology review in prostatectomy specimens: data from the SAKK 09/10 randomized trial on prostate cancer. BJU Int. 2017 Nov;120(5B):E45-E51. doi: 10.1111/bju.13742. Epub 2017 Jan 19. PubMed PMID: 27987524.

3. Keller MD, Neppl C, Irmak Y, Hall SR, Schmid RA, Langer R, Berezowska S. Adverse prognostic value of PD-L1 expression in primary resected pulmonarysquamous cell carcinomas and paired mediastinal lymph node metastases. Mod Pathol. 2017 Sep 8. doi: 10.1038/modpathol.2017.111. [Epub ahead of print] PubMed PMID: 28884747.

4. Laedrach C, Salhia B, Cihoric N, Zlobec I, Tapia C. Immunophenotypic profile of tumor buds in breast cancer. Pathol Res Pract. 2017 Dec 5. pii: S0344-0338(17)30846-4. doi: 10.1016/j.prp.2017.11.023. [Epub ahead of print] PubMed PMID: 29254793.

5. Marinoni I, Wiederkeher A, Wiedmer T, Pantasis S, Di Domenico A, Frank R, Vassella E, Schmitt A, Perren A. Hypo-methylation mediates chromosomalinstability in pancreatic NET. Endocr Relat Cancer. 2017 Mar;24(3):137- 146. doi: 10.1530/ERC-16-0554. Epub 2017 Jan 23. PubMed PMID: 28115389.

6. Bichsel CA, Wang L, Froment L, Berezowska S, Müller S, Dorn P, Marti TM, Peng RW, Geiser T, Schmid RA, Guenat OT, Hall SRR. Increased PD-L1 expression and IL-6 secretion characterize human lung tumor-derived perivascular-like cells that promote vascular leakage in a perfusable microvasculature model. Sci Rep. 2017 Sep 6;7(1):10636. doi: 10.1038/ s41598-017-09928-1. PubMed PMID: 28878242; PubMed Central PMCID: PMC5587684.

7. Wiedmer T, Blank A, Pantasis S, Normand L, Bill R, Krebs P, Tschan MP, Marinoni I, Perren A. Autophagy Inhibition Improves Sunitinib Efficacy in Pancreatic Neuroendocrine Tumors via a Lysosome-dependent Mechanism. Mol Cancer Ther. 2017 Nov;16(11):2502-2515. doi: 10.1158/1535- 7163.MCT-17-0136. Epub 2017 Jul 20. PubMed PMID: 28729403.

8. Ebener S, Barnowski S, Wotzkow C, Marti TM, Lopez-Rodriguez E, Crestani B, Blank F, Schmid RA, Geiser T, Funke M. Toll-like receptor 4 activation attenuates profibrotic response in control lung fibroblasts but not in fibroblasts from patients with IPF. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L42-L55. doi: 10.1152/ajplung.00119.2016. Epub 2016 Nov 4. PubMed PMID: 27815256.

9. Mager LF, Koelzer VH, Stuber R, Thoo L, Keller I, Koeck I, Langenegger M, Simillion C, Pfister SP, Faderl M, Genitsch V, Tcymbarevich I, Juillerat P, Li X, Xia Y, Karamitopoulou E, Lyck R, Zlobec I, Hapfelmeier S, Bruggmann R, McCoy KD, Macpherson AJ, Müller C, Beutler B, Krebs P. The ESRP1-GPR137 axis contributes to intestinal pathogenesis. Elife. 2017 Oct 4;6. pii: e28366. doi: 10.7554/eLife.28366. PubMed PMID: 28975893; PubMed Central PMCID: PMC5665647