Group Diamantis

The main interest of the group is the study of the tumor microenvironment of the ductal pancreatic adenocarcinoma (PDAC). This includes the characterization of the tumor cells with special focus on the Epithelial-Mesenchymal Transition (EMT)-like tumor budding cells at the invasive front of PDAC, as well as the stromal cells and the immune cells surrounding them.  Our aim is the identification of genetic and epigenetic changes of the different cell populations that promote the aggressive (EMT)-like tumor budding phenotype in PDAC.

Current research projects

Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer

Group Diamantis By integrating immune cell background, molecular, and histomorphologic data, we describe three distinct, clinically/ biologically relevant pancreatic ductal adenocarcinoma (PDAC) subtypes: "immune escape," "immune rich," and "immune exhausted." These largely correspond to previously described molecular PDAC subtypes, thus providing a recognizable morphologic substrate integrating host immune response patterns with tumor-associated factors, including molecular features and biologic behavior of the tumors. This will enable the translation of molecular findings into clinically relevant information and may provide a basis for a more successful and individualized therapeutic approach.

CCR 2018 (PDF, 1.3 MB)

Graphic: Immune phenotypes of pancreatic cancer

News

2015 Tiniakos-Award for best contribution in GI-Pathology, 27th European Congress of Pathology

Eva Diamantis-Karamitopoulou, Indications for a strategic role of the stromal cells in the tumour progression of pancreatic cancer. Our investigations show that stromal cells in the tumour microenvironment of tumour buds at the invasion front of pancreatic cancer regulate tumour progression through genetic and epigenetic changes, including expression of miRNAs.

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